Dexamethasone Use in Perioperative Neuroscience : Boon or Bane, or Both?
Dexamethasone is a synthetic corticosteroid that acts almost exclusively on glucocorticoid receptors. Its purported benefits are wide-ranging, and its use in neurosurgery and neuroanesthesia is ubiquitous. The ability of dexamethasone to reduce peritumoral cerebral edema was heralded as “one of t...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health, Inc.
2023
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| Subjects: | |
| Online Access: | http://ir.unimas.my/id/eprint/42804/3/Dexamethasone%20-%20Copy.pdf http://ir.unimas.my/id/eprint/42804/ https://journals.lww.com/jnsa/fulltext/2023/10000/dexamethasone_use_in_perioperative_neuroscience_.2.aspx |
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| Institution: | Universiti Malaysia Sarawak |
| Language: | English |
| Summary: | Dexamethasone is a synthetic corticosteroid that acts
almost exclusively on glucocorticoid receptors. Its
purported benefits are wide-ranging, and its use in neurosurgery and neuroanesthesia is ubiquitous. The ability
of dexamethasone to reduce peritumoral cerebral edema was heralded as “one of the greatest translational research
discoveries in neurosurgery.”1 In neuroanesthesia, the
many benefits of dexamethasone have made it one of the
anesthetist’s “go to” drugs for most neurosurgical cases,
not just intracranial procedures. Currently, this enthusiasm does not seem to be dampened by the drug’s many
adverse effects or the lack of evidence for optimal dosing.
Therefore, before we reach for the syringe, the potential
benefits of dexamethasone must be weighed against
dexamethasone-associated morbidity. |
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