Myocardial fibrosis induced by nonylphenol and its regulatory effect on the TGF-β1/LIMK1 signaling pathway

• Main Authors: Guo, Mei, Xu, Jie, Long, Xianping, Liu, Weichu, Aris, Ahmad Zaharin, Yang, Danli, Luo, Ya, Xu, Yuzhu, Yu, Jie
• Format: Article
• Language: English
• Published: Elsevier 2024
• Online Access: http://psasir.upm.edu.my/id/eprint/106165/1/1-s2.0-S0147651324001854-main-compressed.pdf; http://psasir.upm.edu.my/id/eprint/106165/; https://www.sciencedirect.com/science/article/pii/S0147651324001854
• Institution: Universiti Putra Malaysia

Objective: We here explored whether perinatal nonylphenol (NP) exposure causes myocardial fibrosis (MF) during adulthood in offspring rats and determined the role of the TGF-β1/LIMK1 signaling pathway in NP-induced fibrosis in cardiac fibroblasts (CFs). Methods and results: Histopathology revealed i...