Reviewing the compounding risks for tuberculosis drug-induced liver injury in a patient with transfusion dependent thalassaemia

• Main Authors: Rofii, Nursafinas, Daut, Ummi Nadira, Lau, Su Yin
• Format: Article
• Language: English
• Published: Universiti Putra Malaysia 2023
• Online Access: http://psasir.upm.edu.my/id/eprint/109343/1/Reviewing%20the%20compounding%20risks%20for%20tuberculosis%20drug-induced%20liver%20injury.pdf; http://psasir.upm.edu.my/id/eprint/109343/; https://medic.upm.edu.my/jurnal_kami/volume_19_2023/mjmhs_vol19_no_4_july_2023-74072
• Institution: Universiti Putra Malaysia

A patient presents with jaundice three weeks into commencement of anti-tuberculosis therapy (ATT). Tuberculosis drug-induced liver injury (TB-DILI) is a main concern in patients commencing ATT. Studies have reported various risk factors associated with TB-DILI, urging vigilance in monitoring liver enzymes in these patients. We aim to review the causes of jaundice in a patient with transfusion dependent thalassaemia commenced on ATT and highlight the risk factors associated with TB-DILI.