A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability

• Main Authors: Lai, Mei I., Garner, Chad, Jiang, Jie, Silver, Nicholas, Best, Steve, Menzel, Stephan, Thein, Swee Lay
• Format: Article
• Language: English
• Published: Cambridge University Press 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/12892/1/A%20twins%20heritability%20study%20on%20alpha%20hemoglobin%20stabilizing%20protein.pdf; http://psasir.upm.edu.my/id/eprint/12892/
• Institution: Universiti Putra Malaysia

Cytotoxic precipitation of free α-globin monomers and its production of reactive oxygen species cause red cell membrane damage that leads to anemia and eventually ineffective erythropoiesis in β-thalassemia. Alpha hemoglobin stabilizing protein (AHSP) was found to bind only to free α-globin monomers...