Cytotoxic Aaptamines from Malaysian Aaptos aaptos.

Cytotoxic Aaptamines from Malaysian Aaptos aaptos.

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chlor...

Full description

Saved in:
Bibliographic Details
Main Authors: Shaari, Khozirah, Kee, Cheng Ling, Mat Rashid, Zalilawati, Tan, Pei Jean, Abas, Faridah, Mohd Raof, Salahudin, Zainal, Zurina, Lajis, Nordin, Mohamad, Habsah, Ali, Abdul Manaf
Format: Article
Language:English
Published: MDPI 2009
Online Access:http://psasir.upm.edu.my/id/eprint/13851/
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Universiti Putra Malaysia
Language: English
Description
Summary:In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.

Similar Items