Cytotoxic Aaptamines from Malaysian Aaptos aaptos.

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chlor...

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Main Authors:	Shaari, Khozirah, Kee, Cheng Ling, Mat Rashid, Zalilawati, Tan, Pei Jean, Abas, Faridah, Mohd Raof, Salahudin, Zainal, Zurina, Lajis, Nordin, Mohamad, Habsah, Ali, Abdul Manaf
Format:	Article
Language:	English
Published:	MDPI 2009
Online Access:	http://psasir.upm.edu.my/id/eprint/13851/
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Institution:	Universiti Putra Malaysia
Language:	English

id	my.upm.eprints.13851
record_format	eprints
spelling	my.upm.eprints.138512013-11-06T03:37:17Z http://psasir.upm.edu.my/id/eprint/13851/ Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells. MDPI 2009 Article PeerReviewed Shaari, Khozirah and Kee, Cheng Ling and Mat Rashid, Zalilawati and Tan, Pei Jean and Abas, Faridah and Mohd Raof, Salahudin and Zainal, Zurina and Lajis, Nordin and Mohamad, Habsah and Ali, Abdul Manaf (2009) Cytotoxic Aaptamines from Malaysian Aaptos aaptos. Marine Drugs, 7 (1). pp. 1-8. ISSN 1660-3397 10.3390/md7010001 English
institution	Universiti Putra Malaysia
building	UPM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Putra Malaysia
content_source	UPM Institutional Repository
url_provider	http://psasir.upm.edu.my/
language	English
description	In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells.
format	Article
author	Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf
spellingShingle	Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
author_facet	Shaari, Khozirah Kee, Cheng Ling Mat Rashid, Zalilawati Tan, Pei Jean Abas, Faridah Mohd Raof, Salahudin Zainal, Zurina Lajis, Nordin Mohamad, Habsah Ali, Abdul Manaf
author_sort	Shaari, Khozirah
title	Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
title_short	Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
title_full	Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
title_fullStr	Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
title_full_unstemmed	Cytotoxic Aaptamines from Malaysian Aaptos aaptos.
title_sort	cytotoxic aaptamines from malaysian aaptos aaptos.
publisher	MDPI
publishDate	2009
url	http://psasir.upm.edu.my/id/eprint/13851/
_version_	1643825455016443904

Cytotoxic Aaptamines from Malaysian Aaptos aaptos.

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