Cytotoxic Aaptamines from Malaysian Aaptos aaptos.

• Main Authors: Shaari, Khozirah, Kee, Cheng Ling, Mat Rashid, Zalilawati, Tan, Pei Jean, Abas, Faridah, Mohd Raof, Salahudin, Zainal, Zurina, Lajis, Nordin, Mohamad, Habsah, Ali, Abdul Manaf
• Format: Article
• Language: English
• Published: MDPI 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/13851/
• Institution: Universiti Putra Malaysia

In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chlor...