Effect of pre-germination time of brown rice on serum cholesterol levels of hypercholesterolaemic rats.

• Main Authors: Roohinejad, Shahin, Omidizadeh, Alireza, Mirhosseini, Hamed, Saari, Nazamid, Mustafa, Shuhaimi, Mohd Yusof, Rokiah, Hussin, Anis Shobirin, Abdul Hamid, Azizah, Abd. Manap, Mohd. Yazid
• Format: Article
• Language: English; English
• Published: Wiley-Blackwell 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/24036/1/Effect%20of%20pre-germination%20time%20of%20brown%20rice%20on%20serum%20cholesterol%20levels%20of%20hypercholesterolaemic%20rats..pdf; http://psasir.upm.edu.my/id/eprint/24036/; http://www.wiley.com/
• Institution: Universiti Putra Malaysia

Background: Brown rice is unpolished rice with immeasurable benefits for human health. Brown rice (BR) and pre-germinated brown rice (PGBR) are known to contain various functional compounds such as gamma-oryzanol, dietary fibre and gamma-aminobutyric acid (GABA). In the present study, the experimental diets containing BR and PGBR (24, 48 h pre-germination) were used to investigate the influence of pre-germination time of brown rice on blood cholesterol in Sprague-Dawley male rats. Result: Hypercholesterolaemia and elevation of LDL-cholesterol were successfully ameliorated by the experimental diets containing BR and PGBR (24 and 48 h pre-germination). As compared to the control sample, the pre-germination time had a significant (P < 0.05) effect on blood cholesterol of Sprague-Dawley male rats. It was also found that the significantly (P < 0.05) better effect on lipid profile of hypercholesterolaemic rats was observed by prolonging the pre-germination time. As compared to non-germinated brown rice, the germinated brown rice showed the higher cardio-protective effect on hypercholesterolaemic Sprague-Dawley male rats. Conclusion: The present study suggests that the changes of blood cholesterol can be mainly modulated by using the PGBR rather than BR. The prolonging of pre-germination time led to an increase in the bioactive components, thereby providing a more efficient functional diet affecting the high blood cholesterol. This study suggests that PGBR can be used instead of BR and polished rice in the human diet.