Upregulation of genes related to bone formation by y-amino butyric acid and y-oryzanol in pre-germinated brown rice is via the activation of GABAB-receptors and reduction in serum IL-6 in rats

• Main Authors: Muhammad Sani, Ismaila, Ismail, Maznah, Mahmud, Rozi, Abu Bakar @ Zakaria, Md Zuki, Imam, Mustapha Umar
• Format: Article
• Language: English
• Published: Dove Medical Press 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/29627/1/29627.pdf; http://psasir.upm.edu.my/id/eprint/29627/; https://www.dovepress.com/upregulation-of-genes-related-to-bone-formation-by-gamma-amino-butyric-peer-reviewed-article-CIA
• Institution: Universiti Putra Malaysia

Background: Osteoporosis and other bone degenerative diseases are among the most challenging non-communicable diseases to treat. Previous works relate bone loss due to osteoporosis with oxidative stress generated by free radicals and inflammatory cytokines. Alternative therapy to hormone replacemen...