Pharmacologically antagonizing the CXCR4-CXCL12 chemokine pathway with AMD3100 inhibits sunlight-induced skin cancer

• Main Authors: Sarchio, Seri Narti Edayu, Scolyer, Richard A., Beaugie, Clare, McDonald, David, Marsh-Wakefield, Felix, Halliday, Gary M., Byrne, Scott N.
• Format: Article
• Language: English
• Published: Nature Publishing Group 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/34895/1/Pharmacologically%20antagonizing%20the%20CXCR4.pdf; http://psasir.upm.edu.my/id/eprint/34895/; http://www.nature.com/jid/journal/v134/n4/abs/jid2013424a.html
• Institution: Universiti Putra Malaysia

One way sunlight causes skin cancer is by suppressing anti-tumor immunity. A major mechanism involves altering mast cell migration via the C-X-C motif chemokine receptor 4–C-X-C motif chemokine ligand 12 (CXCR4-CXCL12) chemokine pathway. We have discovered that pharmacologically blocking this pathwa...