Distribution and haplotype associations of XPD Lys751Gln, XRCC1 Arg280His and XRCC1 Arg399Gln polymorphisms with nasopharyngeal carcinoma in the Malaysian population

• Main Authors: Visuvanathan, Shaneeta, Chong, Pei Pei, Yap, Yoke Yeow, Lim, Chin Chye, Tan, Meng Khuan, Lye, Munn Sann
• Format: Article
• Published: West Asia Organization for Cancer Prevention (WAOCP), APOCP's West Asia Chapter 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/37125/; https://journal.waocp.org/article_28989.html
• Institution: Universiti Putra Malaysia

Background: DNA repair pathways play a crucial role in maintaining the human genome. Previous studiesassociated DNA repair gene polymorphisms (XPD Lys751Gln, XRCC1 Arg280His and XRCC1 Arg399Gln)with nasopharyngeal carcinoma. These non-synonymous polymorphisms may alter DNA repair capacity andthus in...