Novel furan-containing peptide-based inhibitors of protein arginine deiminase type IV (PAD4)

• Main Authors: Teo, Chian Ying, Tejo, Bimo Ario, Leow, Adam Thean Chor, Salleh, Abu Bakar, Abdul Rahman, Mohd Basyaruddin
• Format: Article
• Language: English
• Published: John Wiley & Sons A/S 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/59664/1/Novel%20furan-containing%20peptide-based%20inhibitors%20of%20protein%20arginine%20deiminase%20type%20IV%20%28PAD4%29.pdf; http://psasir.upm.edu.my/id/eprint/59664/; http://onlinelibrary.wiley.com/wol1/doi/10.1111/cbdd.13033/abstract
• Institution: Universiti Putra Malaysia

Protein arginine deiminase type IV (PAD4) is responsible for the posttranslational conversion of peptidylarginine to peptidylcitrulline. Citrullinated protein is the autoantigen in rheumatoid arthritis, and therefore, PAD4 is currently a promising therapeutic target for the disease. Recently, we rep...