Neuro-therapeutic benefits of Centella asiatica on some neurodegenerative diseases: a review

• Main Authors: Chiroma, Samaila Musa, Mohd Moklas, Mohamad Aris, Mat Taib, Che Norma, Baharuldin, Mohamad Taufik Hidayat, Jagadeesan, Saravanan, Amom, Zulkhairi, Ibrahim, Bulama
• Format: Article
• Language: English
• Published: RJPBCS 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/62523/1/NEURO.pdf; http://psasir.upm.edu.my/id/eprint/62523/; https://www.researchgate.net/publication/331356684_Neuro-therapeutic_Benefits_of_Centella_asiatica_on_Some_Neurodegenerative_Diseases_A_Review/link/5c7577ca458515831f728cbc/download
• Institution: Universiti Putra Malaysia

Medicinal herbalism has become popular because of its documented efficacy, synergistic interactions against complex conditions and lesser side effects. CA (CA) is a traditional Ayurveda medicine widely used in India, China, and Malaysia and across countries in south-eastern Asia for treating a range of diseases. The whole plant or its parts (leaf or roots) are used for medicinal purpose and its chemical constituents have been proven scientifically to have neuro-protective, wound healing, anti-inflammatory and antioxidants activities. In this review we have retrieved and evaluated available literatures on neuro-therapeutic properties of CA on neurotoxic and transgenic models of Alzheimer’s diseases (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). The extract was found to have neuroprotective ability through modifying a key signaling pathways and events concerned with neuro-degeneration. Further research is required to discover more bioactive compounds of CA and their exact mode of action.