Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata

• Main Authors: Chew, Shu Yih, Ho, Kok Lian, Cheah, Yoke Kqueen, Ng, Tzu Shan, Sandai, Doblin, Brown, Alistair J. P., Than, Leslie Thian Lung
• Format: Article
• Published: Nature Publishing Group 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/80001/; https://www.nature.com/articles/s41598-019-39117-1#:~:text=In%20conclusion%2C%20a%20functional%20glyoxylate,potential%20for%20future%20therapeutic%20intervention.
• Institution: Universiti Putra Malaysia

The human fungal pathogen Candida glabrata appears to utilise unique stealth, evasion and persistence strategies in subverting the onslaught of host immune response during systemic infection. However, macrophages actively deprive the intracellular fungal pathogen of glucose, and therefore alternativ...