Lactococcus lactis harbouring Ara h 2.02 alleviates allergen-specific Th2-associated responses in sensitized mice

• Main Authors: Chan, Chong Joo, Yong, Yen Su, Song, Adelene Ai Lian, Abdul Rahim, Raha, In, Lionel Lian Aun, Lim, Renee Lay Hong
• Format: Article
• Language: English
• Published: Wiley 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/89540/1/ARA.pdf; http://psasir.upm.edu.my/id/eprint/89540/; https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/jam.14524
• Institution: Universiti Putra Malaysia

Aim: To study the prophylactic effect of recombinant Lactococcus lactis (rLl) harbouring Ara h 2.02 peanut allergen, in sensitized and challenged mice. Methods and results: Ara h 2.02 cDNA was cloned into pNZ8048 for heterologous expression in L. lactis. The purified recombinant allergen showed IgE...