MMP-9: biomarker for abdominal aneurysm

• Main Authors: C. A., Affirul, I. M., Azim, H., Hanafiah, K. Nor, Azmi, Z., Rozman
• Format: Article
• Language: English
• Published: Soc Editrice University 2015
• Subjects: Biochemical markers; Abdominal Aortic Aneurysm; MMP-9
• Institution: Universiti Sains Islam Malaysia

Introduction. Matrix Metalloproteinase 9 (MMP-9) has been shown to express significantly on organ tissue culture in Abdominal Aortic Aneurysm (AAA) patients. Prior studies have shown the correlation between MMP-9 concentration levels with AAA raising the probability of its usage as a biomarker in AAA disease. However, results of previous studies have been conflicting. The purpose of this study is to identify the correlation between MMP-9 concentration levels with AAA disease and further define the utility as a biomarker for our center population. Materials and Methods. This is prospective controlled trial. Peripheral venous blood sample is obtained from 20 patients with AAA and 36 normal control subjects. MMP-9 concentration levels were determined by an enzyme-linked immunosorbent assay and compared with subjects abdominal ultrasonography or computed tomography of abdomen. Results. Mean (+/- SE) MMP-9 was 23.94 +/- 0.60 ng/mL in normal control subjects and 21.39 +/- 1.03 ng/mL in patients with AAAs (p <= 0.05 versus normal control subjects). MMP-9 correlate significantly with AAA (p=0.004). There was no correlation of MMP-9 levels with age, gender, or other risk factors. The cutoff point is 12.54 for aorta size <3.0cm. The sensitivity and specificity of MMP-9 were 60% and 64% respectively. Conclusions. MMP-9 levels correlate significantly with AAA with a cutoff point of 12.54. However, the utility of MMP-9 as a diagnostic test is limited due to low sensitivity and specificity. An elevated MMP-9 has limited use to predict the presence of AAA (positive predictive value: 60%) and a normal MMP-9 level was insufficient to determine the absence of AAA (negative predictive value: 36.1%).