Synthesis And Activity Studies Of Novel Dispiro Pyrrolidine Compounds As Potential Antimycobacterial Agents

Sekumpulan dispiro pirolidina yang mengandungi lima puluh dua sebatian telah berjaya disintesis dengan menggunakan penambahan siklo 1,3 dwikutub. Tindak balas ini terbukti sangat regioselektif, menghasilkan satu set regioisomer sahaja sebagai produk. A mini library of fifty two highly functional...

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Bibliographic Details
Main Author: Ang , Chee Wei
Format: Thesis
Language:English
Published: 2015
Subjects:
Online Access:http://eprints.usm.my/30432/1/ANG_CHEE_WEI.pdf
http://eprints.usm.my/30432/
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Institution: Universiti Sains Malaysia
Language: English
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Summary:Sekumpulan dispiro pirolidina yang mengandungi lima puluh dua sebatian telah berjaya disintesis dengan menggunakan penambahan siklo 1,3 dwikutub. Tindak balas ini terbukti sangat regioselektif, menghasilkan satu set regioisomer sahaja sebagai produk. A mini library of fifty two highly functionalized dispiro pyrrolidines were synthesized successfully using 1,3-dipolar cycloaddition. This reaction is proved to be highly regioselective, giving only one set of regioisomer as product.