Anti-proliferative, apoptotic induction, and anti-migration effects of hemi-synthetic 1′S-1′-acetoxychavicol acetate analogs on MDA-MB-231 breast cancer cells

• Main Authors: Su, Ki Liew, Azmi, Mohamad Nurul, LA In, Lionel, Awang, Khalijah, Nagoor, Noor Hasima
• Format: Article
• Language: English
• Published: Dove Medical Press 2017
• Subjects: QD1-999 Chemistry
• Online Access: http://eprints.usm.my/38342/1/Anti-proliferative%2C_apoptotic_induction%2C_and_anti-migration_effects_of_hemi-synthetic.pdf; http://eprints.usm.my/38342/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609789/
• Institution: Universiti Sains Malaysia

Nine analogs of 1′S-1′-acetoxychavicol acetate (ACA) were hemi-synthesized and evaluated for their anticancer activities against seven human cancer cell lines. The aim of this study was to investigate the anti-proliferative, apoptotic, and anti-migration effects of these compounds and to explore the...