Autonomic Nervous System Mediates the Hypotensive Effects of Aqueous and Residual Methanolic Extracts of Syzygium polyanthum (Wight) Walp. var. polyanthum Leaves in Anaesthetized Rats

• Main Authors: Ismail, A., Mohamed, M., Sulaiman, S. A., Wan Ahmad, W. A. N.
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2013
• Subjects: QP Physiology; RM Therapeutics. Pharmacology
• Online Access: http://eprints.usm.my/38379/1/Autonomic_Nervous_System_Mediates_the_Hypotensive_Effects_of_Aqueous_and_Residual.pdf; http://eprints.usm.my/38379/; http://dx.doi.org/10.1155/2013/716532
• Institution: Universiti Sains Malaysia

Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100mg/kg AESP caused mild bradycardia (