Antihyperlipidemic Activity Of Polygonum Minus And Elucidation Of Its Mechanism Of Action

• Main Author: Varghese, Christapher Parayil
• Format: Thesis
• Language: English
• Published: 2017
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/47652/1/ANTIHYPERLIPIDEMIC%20ACTIVITY.pdf%20cut.pdf; http://eprints.usm.my/47652/
• Institution: Universiti Sains Malaysia

Present study aims to evaluate the antihyperlipidemic effect including possible mechanism, antioxidant capacity and toxicities of extract of P. minus leaves. In acute antihyperlipidemic study, the effect of aqueous and methanol extracts of P. minus leaves (1000 mg/kg) were tested on poloxamer-407 induced acute hyperlipidemia in rats. Atorvastatin (60 mg/kg) was used as standard drug. The study showed that both extracts reduced the total cholesterol (TC), triglycerides (TG), LDL, VLDL, atherogenic index, and increased HDL levels when compared with hyperlipidemic control and the effect was higher in methanol extract when compared to aqueous extract.