Rapid microwave assisted synthesis and characterization of nanosized silver-doped hydroxyapatite with antibacterial properties

• Main Authors: Iqbal, Nida, Abdul Kadir, Mohammed Rafiq, Nik Malek, Nik Ahmad Nizam, Mahmood, Nasrul Humaimi, Murali, Malliga Raman, Kamarul, Tunku
• Format: Article
• Published: Elsevier 2012
• Subjects: R Medicine (General)
• Online Access: http://eprints.utm.my/id/eprint/33483/; http://dx.doi.org/10.1016/j.matlet.2012.08.057
• Institution: Universiti Teknologi Malaysia

Synthesis of nanosized particles of silver-doped hydroxyapatite (Ag-HA) as an antibacterial agent is of potential importance in managing infections associated with surgical implants. However, the process of synthesizing this agent is time consuming and inefficient. To overcome this problem, a rapid method for synthesizing nano-sized Ag-doped hydroxyapatite (Ag-HA) [Ca 10-xAg x(PO 4) 6(OH) 2] (x=0.03-0.5) using microwave irradiation for 10 min at 800 W is proposed. The materials were characterized using XRD, FTIR, FESEM and EDX. Antibacterial behavior of the Ag-HA samples were evaluated using disc diffusion technique and results demonstrated good activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli.