A newton cooperative genetic algorithm method for in silico optimization of metabolic pathway production

• Main Authors: Ismail, Mohd. Arfian, Deris, Safaai, Aberi Mohamad, Mohd Saberi, Abdullah, Afnizanfaizal
• Format: Article
• Published: Public Library of Science 2015
• Subjects: QA76 Computer software
• Online Access: http://eprints.utm.my/id/eprint/55742/; http://dx.doi.org/10.1371/journal.pone.0126199
• Institution: Universiti Teknologi Malaysia

This paper presents an in silico optimization method of metabolic pathway production. The metabolic pathway can be represented by a mathematical model known as the generalized mass action model, which leads to a complex nonlinear equations system. The optimization process becomes difficult when stea...