Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer

• Main Authors: Bharti, Rashmi, Dey, Goutam, Ojha, Probir kumar, Rajput, Shashi, Jaganathan, Saravana Kumar, Sen, Ramkrishna, Mandal, Mahitosh
• Format: Article
• Published: Nature Publishing Group 2016
• Subjects: RC Internal medicine
• Online Access: http://eprints.utm.my/id/eprint/69208/; http://dx.doi.org/10.1038/onc.2015.466
• Institution: Universiti Teknologi Malaysia

Interleukin-6 (IL-6) signaling network has been implicated in oncogenic transformations making it attractive target for the discovery of novel cancer therapeutics. In this study, potent antiproliferative and apoptotic effect of diacerein were observed against breast cancer. In vitro apoptosis was in...