A rapid MCM-41 dispersive micro-solid phase extraction coupled with LC/MS/MS for quantification of ketoconazole and voriconazole in biological fluids

• Main Authors: Yahaya, N., Sanagi, M. M., Abd. Aziz, N., Wan Ibrahim, W. A., Nur, H., Loh, S. H., Kamaruzaman, S.
• Format: Article
• Published: John Wiley and Sons Ltd 2017
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/75431/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85008481895&doi=10.1002%2fbmc.3803&partnerID=40&md5=f55be43f2af37935fe915b5908fbc7e3
• Institution: Universiti Teknologi Malaysia

A rapid dispersive micro-solid phase extraction (D-μ-SPE) combined with LC/MS/MS method was developed and validated for the determination of ketoconazole and voriconazole in human urine and plasma samples. Synthesized mesoporous silica MCM-41 was used as sorbent in d-μ-SPE of the azole compounds fro...