Modeling and optimization of nanoemulsion containing Sorafenib for cancer treatment by response surface methodology

• Main Authors: Izadiyan, Z., Basri, M., Fard Masoumi, H. R., Abedi Karjiban, R., Salim, N., Shameli, K.
• Format: Article
• Language: English
• Published: BioMed Central Ltd. 2017
• Subjects: T Technology (General)
• Online Access: http://eprints.utm.my/id/eprint/75905/1/KamyarShameli_ModelingandOptimizationofNanoemulsion.pdf; http://eprints.utm.my/id/eprint/75905/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014362847&doi=10.1186%2fs13065-017-0248-6&partnerID=40&md5=fc7b069bb32dfd7e4ed579678f1dba17
• Institution: Universiti Teknologi Malaysia

The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy emulsification method and optimized by response surface methodology. The effects of overhe...