Microwave-assisted synthesis of mono- and disubstituted 4-hydroxyacetophenone derivatives via Mannich reaction: synthesis, XRD and HS-analysis

An efficient microwave-assisted one-step synthetic route toward Mannich bases is developed from 4-hydroxyacetophenone and different secondary amines in quantitative yields, via a regioselective substitution reaction. The reaction takes a short time and is non-catalyzed and reproducible on a gram sca...

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Bibliographic Details
Main Authors: Aljohani, Ghadah, Said, Musa A., Lentz, Dieter, Basar, Norazah, Albar, Arwa, Alraqa, Shaya Y., Al-Sheikh Ali, Adeeb
Format: Article
Language:English
Published: MDPI AG 2019
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Online Access:http://eprints.utm.my/id/eprint/89372/1/GhadahAljohani2019_MicrowaveAssistedSynthesisofMonoandDisubstituted.pdf
http://eprints.utm.my/id/eprint/89372/
http://dx.doi.org/10.3390/molecules24030590
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Institution: Universiti Teknologi Malaysia
Language: English