Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitors
Twelve novel chalcones were synthesized using 2-alkyloxy-naphthaldehydes and Mannich bases of 4-hydroxyacetophenone. The chalcones were characterized using FTIR, 1D and 2D NMR and HRMS spectroscopy. Comparative docking analysis was carried out to screen their affinity towards the AChE enzyme (PDB 1E...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Informa UK Limited
2021
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/97601/1/NorazahBasar2021_SynthesisMolecularDockingAndBiochemicalAnalysis.pdf http://eprints.utm.my/id/eprint/97601/ http://dx.doi.org/10.1080/16583655.2021.2005921 |
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| Institution: | Universiti Teknologi Malaysia |
| Language: | English |