Synthesis, molecular docking and biochemical analysis of aminoalkylated naphthalene-based chalcones as acetylcholinesterase inhibitors

• Main Authors: Aljohani, Ghadah, Al-Sheikh Ali, Adeeb, Alraqa, Shaya Y., Amran, Syazwani Itri, Basar, Norazah
• Format: Article
• Language: English
• Published: Informa UK Limited 2021
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/97601/1/NorazahBasar2021_SynthesisMolecularDockingAndBiochemicalAnalysis.pdf; http://eprints.utm.my/id/eprint/97601/; http://dx.doi.org/10.1080/16583655.2021.2005921
• Institution: Universiti Teknologi Malaysia

Twelve novel chalcones were synthesized using 2-alkyloxy-naphthaldehydes and Mannich bases of 4-hydroxyacetophenone. The chalcones were characterized using FTIR, 1D and 2D NMR and HRMS spectroscopy. Comparative docking analysis was carried out to screen their affinity towards the AChE enzyme (PDB 1E...