Development and evaluation antitumor activity of PEGylated liposomal doxorubicin on tumor-bearing BALB/c-Foxn1nu mice model
Doxorubicin hydrochloride is an antitumor antibiotic derived from anthracyclines. It has had limited use because of its dose-related cardiotoxicity and myelosuppression. Liposomes have been used as a vehicle for administration of pharmaceutical drugs because of their ability to improve the deliv...
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| Main Authors: | , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | http://repository.vnu.edu.vn/handle/VNU_123/11443 |
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| 總結: | Doxorubicin hydrochloride is an antitumor antibiotic derived from anthracyclines. It has had limited use because
of its dose-related cardiotoxicity and myelosuppression. Liposomes have been used as a vehicle for
administration of pharmaceutical drugs because of their ability to improve the delivery of drugs to tumors,
increase therapeutic efficacy, and decrease toxicity to normal cells. The aim of this study is to prepare a new
liposomal dxorubicin on a large -scale and evaluate its antitumor activity in vivo. Liposomes were formed using
the hydration of a thin lipid film method, and doxorubicin was loaded through a pH gradient technique. Based on
TEM images, large lamellar vesicles (LUV) were formed, with sizes of 95 ± 10 nm, having a polydispersity
index of 0.138 ± 0.02 and zeta potentials of about -27.8 ± 2.15 mV. The entrapment efficiency was
approximately 97%. The therapeutic activity of PEGylated liposomal doxorubicin formulations was studied on
human colorectal carcinoma HT 29 tumor-bearing BALB/c-Foxn1
nu
mice models. Our results have shown that
liposome preparation can reduce the tumor volume and increase the survival rate and survival time as compared
with Lipo Dox. PEGylated liposomal doxorubicin demonstrated much stronger antitumor activities, and
statistical differences were significant when compared with free doxorubicin. |
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