Multi-output model with Box–Jenkins operators of linear indices to predict multi-target inhibitors of ubiquitin–proteasome pathway

• المؤلفون الرئيسيون: Le, Thi Thu Huong, Gerardo, M. Casañola-Martin, Facundo, Pérez-Giménez, Yovani, Marrero-Ponce
• مؤلفون آخرون: Matilde, Merino-Sanjuán
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Ubiquitin–proteasome pathway inhibitors; CHEMBL; Multi-target; Multi-scale and multi-output models; Moving averages; QSAR
• الوصول للمادة أونلاين: http://repository.vnu.edu.vn/handle/VNU_123/11504

The ubiquitin–proteasome pathway (UPP) plays an important role in the degradation of cellular proteins and regulation of different cellular processes that include cell cycle control, proliferation, differentiation, and apoptosis. In this sense, the disruption of proteasome activity leads to dif-...