Synthesis and characterization of the precursor compounds of a phenolic and pyrazinamide derivative of imidazo[2,1-b][1,3,4]thiadiazole and the evaluation of its predicted absorption, distribution, metabolism, and excretion (ADME) properties

Synthesis and characterization of the precursor compounds of a phenolic and pyrazinamide derivative of imidazo[2,1-b][1,3,4]thiadiazole and the evaluation of its predicted absorption, distribution, metabolism, and excretion (ADME) properties

Tuberculosis (TB) is an infectious disease that has continued to plague society and has caused the mortality of 1.3 million people worldwide in 2022. Among the various approved anti-TB drugs, pyrazinamide (PZA) possesses the unique ability to kill certain semi-dormant TB bacteria that other drugs fa...

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Bibliographic Details
Main Authors: Dy, Isis Maxine O., Shin, Jiyoon
Format: text
Language:English
Published: Animo Repository 2024
Subjects:
Tuberculosis
Phenols
Pyrazinamide
Biochemistry
Online Access:https://animorepository.dlsu.edu.ph/etdb_chem/41
https://animorepository.dlsu.edu.ph/context/etdb_chem/article/1052/viewcontent/2024_Dy_Shin_Synthesis_and_characterization_of_the_precursor_compounds_Full_text.pdf
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Institution: De La Salle University
Language: English

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