A transcriptional repressor co-regulatory network governing androgen response in prostate cancers

• Main Authors: Chng, Kern Rei, Chang, Cheng Wei, Tan, Si Kee, Yang, Chong, Hong, Shu Zhen, Sng, Noel Yan Wei, Cheung, Edwin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/100796; http://hdl.handle.net/10220/13276
• Institution: Nanyang Technological University

Transcriptional corepressors are frequently aberrantly over-expressed in prostate cancers. However, their crosstalk with the Androgen receptor (AR), a key player in prostate cancer development, is unclear. Using ChIP-Seq, we generated extensive global binding maps of AR, ERG, and commonly over-expre...