Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways

• المؤلفون الرئيسيون: De Miguel, Zurine, Manley, Nathan C., Lee, I-Ping, Evans, Andrew K., Yang, Cissy, Works, Melissa G., Kumar, Vineet, Sapolsky, Robert M.
• مؤلفون آخرون: Bogyo, Matthew
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/101134; http://hdl.handle.net/10220/24140
• المؤسسة: Nanyang Technological University

The obligate intracellular parasite, Toxoplasma gondii, disseminates through its host inside infected immune cells. We hypothesize that parasite nutrient requirements lead to manipulation of migratory properties of the immune cell. We demonstrate that 1) T. gondii relies on glutamine for optimal inf...