Cross-reactivity and anti-viral function of dengue capsid and NS3-specific memory T cells toward Zika virus

• المؤلفون الرئيسيون: Lye, David Chienboon, Lim, Mei Qiu, Kumaran, Emmanuelle A. P., Tan, Hwee Cheng, Leo, Yee Sin, Ooi, Eng Eong, MacAry, Paul A., Bertoletti, Antonio, Rivino, Laura
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Zika Virus (ZIKV); Dengue Virus (DENV); DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/103398; http://hdl.handle.net/10220/47310

Zika virus (ZIKV), a flavivirus with homology to dengue virus (DENV), is spreading to areas of DENV hyper-endemicity. Heterologous T cell immunity, whereby virus-specific memory T cells are activated by variant peptides derived from a different virus, can lead to enhanced viral clearance or diminish...