How convergent and divergent signaling pathways are mediated by card-card interactions

• المؤلف الرئيسي: Qin, Gong
• مؤلفون آخرون: Wu Bin
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2020
• الموضوعات: Science::Biological sciences::Biophysics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/137877

PRRs play an essential role in detecting pathogenic infections and propagating such immune signals to downstream effectors. NLRs act as a classic subfamily of PRRs, including NOD1/NOD2 and NLRC4. NOD1 and NOD2 share a same adaptor protein – RIP2 – that is critical for downstream signaling. The CARD...