Adipsic Diabetes Insipidus - the challenging combination of polyuria and adipsia : a case report and review of literature

• المؤلفون الرئيسيون: Dalan, Rinkoo, Chin, Hanxin, Hoe, Jeremy, Chen, Abel, Tan, Huiling, Boehm, Bernhard Otto, Chua, Karen SuiGeok
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Science::Medicine; Adipsia; Diabetes Insipidus
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/142472

Adipsic Diabetes Insipidus is a rare hypothalamic disorder characterized by a loss of thirst in response to hypernatraemia accompanied by diabetes insipidus. These occur secondary to a congregation of defects in the homeostatic mechanisms of water balance. A 27-year old Chinese female presented with Adipsic Diabetes Insipidus after cerebral arteriovenous malformation (AVM) surgery. Initial diagnosis and management was extremely challenging. Long term management required a careful interplay between low dose vasopressin analog treatment and fluids. Detailed charts of medication and sodium balance are described in the case presentation. We performed a literature search of similarly reported cases and describe the possible pathogenesis, etiology, clinical presentation, acute and chronic management, and prognosis.