Plasticity of the 340-loop in influenza neuraminidase offers new insight for antiviral drug development

• المؤلفون الرئيسيون: Han, Nanyu, Ng, Justin Tze Yang, Li, Yanpeng, Mu, Yuguang, Huang, Zunxi
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Biological sciences; Influenza; Neuraminidase
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/146355
• المؤسسة: Nanyang Technological University

The recently discovered 340-cavity in influenza neuraminidase (NA) N6 and N7 subtypes has introduced new possibilities for rational structure-based drug design. However, the plasticity of the 340-loop (residues 342-347) and the role of the 340-loop in NA activity and substrate binding have not been...