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 ______     _____     _  __   _    _     ______  
|      \\  |  ___||  | |/ // | || | ||  /_____// 
|  --  //  | ||__    | ' //  | || | ||  `____ `  
|  --  \\  | ||__    | . \\  | \\_/ ||  /___//   
|______//  |_____||  |_|\_\\  \____//   `__ `    
`------`   `-----`   `-` --`   `---`    /_//     
                                        `-`

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Text this: Thienopyrimidinone derivatives that inhibit bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) by restructuring the active site with a tyrosine-flipping mechanism