Mechanism of polyamine induced colistin resistance through electrostatic networks on bacterial outer membranes

• المؤلفون الرئيسيون: Li, Jianguo, Beuerman, Roger, Verma, Chandra Shekhar
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Biological sciences; Molecular Dynamics Simulations; Low Molecular Weight Linear Polyamine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/152155

Naturally occurring linear polyamines are known to enable bacteria to be resistant to cationic membrane active peptides. To understand this protective mechanism, molecular dynamics simulations are employed to probe their effect on a model bacterial outer membrane. Being protonated at physiological p...