Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles
Hydroxyapatite (HA) nanoparticles have been studied as carriers for the delivery of therapeutic agents. The two important considerations of the carriers are the encapsulation abilities and the release profiles. This report presents a model study of encapsulating and release of model proteins from HA...
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2009
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sg-ntu-dr.10356-153952023-03-04T15:34:19Z Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles Law, Yi Ping. Loo Say Chye Joachim School of Materials Science and Engineering DRNTU::Engineering::Materials::Biomaterials Hydroxyapatite (HA) nanoparticles have been studied as carriers for the delivery of therapeutic agents. The two important considerations of the carriers are the encapsulation abilities and the release profiles. This report presents a model study of encapsulating and release of model proteins from HA nanoparticles. The double inverse microemulsion (DIME) method of synthesis was used to produce HA nanoparticles and encapsulate model proteins within. The effects of synthesis by this method on the size, encapsulation capabilities and release profiles were studied, using the co-precipitation method as a control. The DIME was shown to have encapsulation capabilities but the release results did not show a controlled sustained release. Bachelor of Engineering (Materials Engineering) 2009-04-28T02:56:10Z 2009-04-28T02:56:10Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/15395 en Nanyang Technological University 51 p. application/pdf |
| institution |
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NTU Library |
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Asia |
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Singapore Singapore |
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| topic |
DRNTU::Engineering::Materials::Biomaterials |
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DRNTU::Engineering::Materials::Biomaterials Law, Yi Ping. Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| description |
Hydroxyapatite (HA) nanoparticles have been studied as carriers for the delivery of therapeutic agents. The two important considerations of the carriers are the encapsulation abilities and the release profiles. This report presents a model study of encapsulating and release of model proteins from HA nanoparticles. The double inverse microemulsion (DIME) method of synthesis was used to produce HA nanoparticles and encapsulate model proteins within. The effects of synthesis by this method on the size, encapsulation capabilities and release profiles were studied, using the co-precipitation method as a control. The DIME was shown to have encapsulation capabilities but the release results did not show a controlled sustained release. |
| author2 |
Loo Say Chye Joachim |
| author_facet |
Loo Say Chye Joachim Law, Yi Ping. |
| format |
Final Year Project |
| author |
Law, Yi Ping. |
| author_sort |
Law, Yi Ping. |
| title |
Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| title_short |
Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| title_full |
Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| title_fullStr |
Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| title_full_unstemmed |
Development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| title_sort |
development of encapsulation and release of model proteins in hydroxyapatite nanoparticles |
| publishDate |
2009 |
| url |
http://hdl.handle.net/10356/15395 |
| _version_ |
1759855609501450240 |