Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein

The stringent response, regulated by the bifunctional (p)ppGpp synthetase/hydrolase Rel in mycobacteria, is critical for long-term survival of the drug-tolerant dormant state of Mycobacterium tuberculosis. During amino acid starvation, MtRel senses a drop in amino acid concentration and synthesizes...

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Bibliographic Details
Main Authors: Shin, Joon, Singal, Bharti, Manimekalai, Malathy Sony Subramanian, Wei Chen, Ming, Ragunathan, Priya, Grüber, Gerhard
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
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Online Access:https://hdl.handle.net/10356/154271
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Institution: Nanyang Technological University
Language: English

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