Microencapsulated islet-like microtissues with toroid geometry for enhanced cellular viability

• المؤلفون الرئيسيون: Chen, Yang, Nguyen, Dang Tri, Kokil, Ganesh Rajendra, Wong, Yun Xuan, Dang, Tram Thuy
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Engineering::Chemical engineering; Islet-Like Microtissue; Toroid; Microtissue Geometry; Encapsulation; Diabetes; Cellular Viability
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/161857
• المؤسسة: Nanyang Technological University

Transplantation of immuno-isolated islets is a promising strategy to restore insulin-secreting function in patients with Type 1 diabetes. However, the clinical translation of this treatment approach remains elusive due to the loss of islet viability resulting from hypoxia at the avascular transpl...