Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes

• المؤلفون الرئيسيون: Loh, Jia Tong, Zhang, Bin, Teo, Joey Kay Hui, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Lam, Kong-Peng, Lim, Sai Kiang
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Science::Biological sciences; Science::Medicine; Complements; Exosomes
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/162798
• المؤسسة: Nanyang Technological University

Complements and neutrophils are two key players of the innate immune system that are widely implicated as drivers of severe COVID-19 pathogenesis, as evident by the direct correlation of respiratory failure and mortality with elevated levels of terminal complement complex C5b-9 and neutrophils. In t...