Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice

• المؤلفون الرئيسيون: Akalestou, Elina, Lopez-Noriega, Livia, Christakis, Ioannis, Hu, Ming, Miras, Alexander D., Leclerc, Isabelle, Rutter, Guy A.
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2023
• الموضوعات: Science::Medicine; Bariatric Surgery; Diabetes
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/171046

Glucocorticoids produced by the adrenal cortex are essential for the maintenance of metabolic homeostasis. Glucocorticoid activation is catalysed by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). Excess glucocorticoids are associated with insulin resistance and hyperglycaemia. A small number of stud...