Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults
Dengue cases continue to rise and can overwhelm healthcare systems during outbreaks. In dengue, neutrophil mediators, soluble urokinase plasminogen activator receptor (suPAR) and olfactomedin 4, and mast cell mediators, chymase and tryptase, have not been measured longitudinally across the dengue ph...
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sg-ntu-dr.10356-1748152024-04-14T15:40:48Z Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults Teo, Andrew Le, Chau Thuy Tien Tan, Trevor Chia, Po Ying Yeo, Tsin Wen Lee Kong Chian School of Medicine (LKCMedicine) Tan Tock Seng Hospital National Centre for Infectious Diseases Medicine, Health and Life Sciences Severe dengue Soluble urokinase plasminogen activator receptor Dengue cases continue to rise and can overwhelm healthcare systems during outbreaks. In dengue, neutrophil mediators, soluble urokinase plasminogen activator receptor (suPAR) and olfactomedin 4, and mast cell mediators, chymase and tryptase, have not been measured longitudinally across the dengue phases. The utility of these proteins as prognostic biomarkers for severe dengue has also not been assessed in an older adult population. National Medical Research Council (NMRC) Submitted/Accepted version This work was supported by Clinician Scientist Award INV 15nov007 awarded to T. W. Y., LKCMedicine Dean’s Postdoctoral Fellowship and LKCMedicine-Imperial College collaborative grant awarded to A. T. P. Y. C. was supported by NMRC Research Training Fellowship (NMRC/Fellowship/0056/2018). 2024-04-12T01:16:38Z 2024-04-12T01:16:38Z 2024 Journal Article Teo, A., Le, C. T. T., Tan, T., Chia, P. Y. & Yeo, T. W. (2024). Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults. Clinical Infectious Diseases, 78(3), 788-796. https://dx.doi.org/10.1093/cid/ciad637 1058-4838 https://hdl.handle.net/10356/174815 10.1093/cid/ciad637 37823481 2-s2.0-85188305590 3 78 788 796 en NMRC/Fellowship/0056/2018 Clinical Infectious Diseases © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. This article may be downloaded for personal use only. Any other use requires prior permission of the copyright holder. The Version of Record is available online at http://doi.org/10.1093/cid/ciad637. application/pdf |
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Medicine, Health and Life Sciences Severe dengue Soluble urokinase plasminogen activator receptor |
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Medicine, Health and Life Sciences Severe dengue Soluble urokinase plasminogen activator receptor Teo, Andrew Le, Chau Thuy Tien Tan, Trevor Chia, Po Ying Yeo, Tsin Wen Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| description |
Dengue cases continue to rise and can overwhelm healthcare systems during outbreaks. In dengue, neutrophil mediators, soluble urokinase plasminogen activator receptor (suPAR) and olfactomedin 4, and mast cell mediators, chymase and tryptase, have not been measured longitudinally across the dengue phases. The utility of these proteins as prognostic biomarkers for severe dengue has also not been assessed in an older adult population. |
| author2 |
Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet |
Lee Kong Chian School of Medicine (LKCMedicine) Teo, Andrew Le, Chau Thuy Tien Tan, Trevor Chia, Po Ying Yeo, Tsin Wen |
| format |
Article |
| author |
Teo, Andrew Le, Chau Thuy Tien Tan, Trevor Chia, Po Ying Yeo, Tsin Wen |
| author_sort |
Teo, Andrew |
| title |
Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| title_short |
Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| title_full |
Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| title_fullStr |
Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| title_full_unstemmed |
Febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| title_sort |
febrile phase soluble urokinase plasminogen activator receptor and olfactomedin 4 as prognostic biomarkers for severe dengue in adults |
| publishDate |
2024 |
| url |
https://hdl.handle.net/10356/174815 |
| _version_ |
1806059739595931648 |