Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

One potential approach for treating obesity is to increase energy expenditure in brown and white adipose tissue. Here we aimed to achieve this outcome by targeting mitochondrial uncoupler compounds selectively to adipose tissue, thus avoiding side effects from uncoupling in other tissues. Selective...

Saved in:

書目詳細資料
Main Authors:	Ng, Mei Ying, Song, Zhi Jian, Venkatesan, Gopalakrishnan, Rodriguez-Cuenca, Sergio, West, James A., Yang, Shili, Tan, Choon Hong, Ho, Paul Chi-Lui, Griffin, Julian L., Vidal-Puig, Antonio, Bassetto, Marcella, Hagen, Thilo
其他作者:	School of Physical and Mathematical Sciences
格式:	Article
語言:	English
出版:	2024
主題:	Chemistry Adipose tissue Energy metabolism
在線閱讀:	https://hdl.handle.net/10356/174947
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

相似書籍

Adiposity impacts cognitive function in Asian populations: an epidemiological and Mendelian Randomization study
由: Mina, Theresia, et al.
出版: (2023)

Comparative Study of Adipose-Derived Stem Cells From Abdomen and Breast
由: Guneta, Vipra, et al.
出版: (2017)

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
由: Martinez, Nuria, et al.
出版: (2019)

De novo reconstruction of human adipose transcriptome reveals conserved lncRNAs as regulators of brown adipogenesis
由: Ding, Chunming, et al.
出版: (2018)

Associations of childcare arrangements with adiposity measures in a multi-ethnic Asian cohort: the GUSTO study
由: Wong, Beverly Wen-Xin, et al.
出版: (2022)

Characteristics of adipose-derived stem cells isolated from buccal fat pads using CD 271 cell sorting technique
由: Monsikan Phopetch
出版: (2023)

Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis
由: Than, Aung, et al.
出版: (2021)

ANRIL promoter DNA methylation : a perinatal marker for later adiposity
由: Lillycrop, Karen, et al.
出版: (2018)

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
由: Kolak, M., et al.
出版: (2016)

Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding RNA regulators
由: Bai, Zhiqiang, et al.
出版: (2018)

MOLECULAR DETERMINANTS OF HUMAN ADIPOSE FUNCTION AND THEIR ROLE IN THE PATHOGENESIS OF OBESITY AND DIABETES
由: MADHUR AGRAWAL
出版: (2016)

Postmenopausal chinese-singaporean women have a higher ratio of visceral to subcutaneous adipose tissue volume than caucasian women of the same age and bmi
由: Kalimeri, Maria, et al.
出版: (2022)

Female adiposity and time-to-pregnancy: A multiethnic prospective cohort
由: Loy S.L., et al.
出版: (2021)

A synopsis of brown adipose tissue imaging modalities for clinical research
由: Sun L., et al.
出版: (2020)

Characterization of human adipose tissue-derived adult multipotent precursor cells
由: LEONG TAI WEI, DAVID
出版: (2010)

The kynurenine pathway metabolites in cord blood positively correlate with early childhood adiposity.
由: Tan, Karen Mei-Ling, et al.
出版: (2022)

Adipose-derived progenitor cells profiling and cartilage tissue engineering in combination with matrix and three dimensional porous scaffolds
由: MONIQUE MARTINA
出版: (2010)

Adverse associations between visceral adiposity, brain structure, and cognitive performance in healthy elderly
由: Isaac, V., et al.
出版: (2014)

Delivery of basic fibroblast growth factors from heparinized decellularized adipose tissue stimulates potent de novo adipogenesis
由: Lu, Q., et al.
出版: (2014)

Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE)
由: Sun, Lijuan, et al.
出版: (2022)

ATF5, a possible regulator of osteogenic differentiation in human adipose-derived stem cells
由: Leong, D.T., et al.
出版: (2014)

Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the coronary artery risk development in young adults study
由: Oh, Minsuk, et al.
出版: (2024)

SILK-BASED TISSUE ENGINEERED INTERVERTEBRAL DISC USING ADIPOSE-DERIVED STEM CELLS
由: NEO PUAY YONG
出版: (2015)

Recellularization of decellularized adipose tissue-derived stem cells : role of the cell-secreted extracellular matrix in cellular differentiation
由: Guneta, Vipra, et al.
出版: (2020)

Automated segmentation of visceral, deep subcutaneous, and superficial subcutaneous adipose tissue volumes in MRI of neonates and young children
由: Kway, YM, et al.
出版: (2022)

Associations of childcare arrangements with adiposity measures in a multi-ethnic Asian cohort: The gusto study
由: Wong, BWX, et al.
出版: (2022)

Late-Pregnancy Fetal Hypoxia Is Associated With Altered Glucose Metabolism and Adiposity in Young Adult Offspring of Women With Type 1 Diabetes
由: Klemetti, Miira M., et al.
出版: (2022)

Characterization of osteogenically induced adipose tissue-derived precursor cells in 2-dimensional and 3-dimensional environments
由: Leong, D.T., et al.
出版: (2014)

Eating behaviors moderate the associations between risk factors in the first 1000 days and adiposity outcomes at 6 years of age
由: Fogel A., et al.
出版: (2021)

Capsinoids activate brown adipose tissue (BAT) with increased energy expenditure associated with subthreshold 18-fluorine fluorodeoxyglucose uptake in BAT-positive humans confirmed by positron emission tomography scan
由: Sun, Lijuan, et al.
出版: (2020)

Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic study.
由: Tai, Yee Kit, et al.
出版: (2020)

Enhanced endothelial differentiation of adipose-derived stem cells by substrate nanotopography
由: Shi, Z., et al.
出版: (2014)

Adiposity and metabolic health in Asian populations: an epidemiological study using dual-energy x-ray absorptiometry in Singapore
由: Mina, Theresia, et al.
出版: (2024)

Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs
由: Reid, D.W, et al.
出版: (2020)

Investigation of Osteogenic characteristics of human adipose derived stromal cells
由: MOHAN CHOTHIRAKOTTU ABRAHAM
出版: (2010)

Osteo-maturation of adipose-derived stem cells required the combined action of vitamin D3, β-glycerophosphate, and ascorbic acid
由: Gupta, A., et al.
出版: (2014)

Precipitation of nanohydroxyapatite on PLLA/PBLG/Collagen nanofibrous structures for the differentiation of adipose derived stem cells to osteogenic lineage
由: Ravichandran, R., et al.
出版: (2014)

TARGETING CHOLESTEROL ACCUMULATION USING CYCLODEXTRIN AS POTENTIAL LYMPHEDEMA TREATMENT
由: MOHAMED AMEEN SHAH BIN MOHAMED YUNOS
出版: (2024)

CD137 negatively affects "browning" of white adipose tissue during cold exposure
由: RAJ KAMAL SRIVASTAVA, et al.
出版: (2021)

Buckled structures and 5-azacytidine enhance cardiogenic differentiation of adipose-derived stem cells
由: Ravichandran, R., et al.
出版: (2014)