Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

• المؤلفون الرئيسيون: Ng, Mei Ying, Song, Zhi Jian, Venkatesan, Gopalakrishnan, Rodriguez-Cuenca, Sergio, West, James A., Yang, Shili, Tan, Choon Hong, Ho, Paul Chi-Lui, Griffin, Julian L., Vidal-Puig, Antonio, Bassetto, Marcella, Hagen, Thilo
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2024
• الموضوعات: Chemistry; Adipose tissue; Energy metabolism
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/174947
• المؤسسة: Nanyang Technological University

One potential approach for treating obesity is to increase energy expenditure in brown and white adipose tissue. Here we aimed to achieve this outcome by targeting mitochondrial uncoupler compounds selectively to adipose tissue, thus avoiding side effects from uncoupling in other tissues. Selective...