Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation

One potential approach for treating obesity is to increase energy expenditure in brown and white adipose tissue. Here we aimed to achieve this outcome by targeting mitochondrial uncoupler compounds selectively to adipose tissue, thus avoiding side effects from uncoupling in other tissues. Selective...

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Main Authors: Ng, Mei Ying, Song, Zhi Jian, Venkatesan, Gopalakrishnan, Rodriguez-Cuenca, Sergio, West, James A., Yang, Shili, Tan, Choon Hong, Ho, Paul Chi-Lui, Griffin, Julian L., Vidal-Puig, Antonio, Bassetto, Marcella, Hagen, Thilo
其他作者: School of Physical and Mathematical Sciences
格式: Article
語言:English
出版: 2024
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在線閱讀:https://hdl.handle.net/10356/174947
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