Interaction of SIRT6 with telomeric chromatin in the context of ageing and cancer

• المؤلف الرئيسي: Teh, Zhi Jing
• مؤلفون آخرون: Lars Nordenskiöld
• التنسيق: Final Year Project
• اللغة: English
• منشور في: Nanyang Technological University 2024
• الموضوعات: Medicine, Health and Life Sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/175445
• المؤسسة: Nanyang Technological University

Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with known functions in maintaining telomere integrity and cellular homeostasis. Early reports revealed the role of SIRT6 as a histone deacetylase while increasing studies have shown the protein’s involvement in regulating chromatin organisation. Whi...