Combatting pathogenic bacteria with synthetic immunotherapeutics from chitosan: antibody recruiting at engineered bacterial surface with peptidoglycan analogs

• Main Authors: Xu, Yuan, Song, Shihao, Duan, Hongwei, Deng, Yinyue, Liu, Xue-Wei
• Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
• Format: Article
• Language: English
• Published: 2024
• Subjects: Medicine, Health and Life Sciences; Chitosan; Bacterial infection
• Online Access: https://hdl.handle.net/10356/178867
• Institution: Nanyang Technological University

The emergence of microbial drug resistance, coupled with the paucity of new antibiotics poses an impending threat to public health. In this work, we drew inspiration from synthetic peptidoglycan oligomers and successfully constructed antibody-recruiting peptidoglycan analogs, 2a-d, with excellent sa...